Cisplatin mouse
WebDec 8, 2024 · Cisplatin treatment induced similar responses for body and organ weights, serum analyzing factors, and blood analyzing factors in all BALB/c substrains with CT26 syngeneic tumor. Few differences were detected in the volume and histopathological structure of the CT26 tumor. WebMay 11, 2012 · Mice were given LPs-pVAX or LPs-pVAX-LKB1 complexes by intratumoral injection at a dose of 20 μg per mice and/or low-dose cisplatin (2 mg kg −1 per mice) by i.p injection. After 24 h of the ...
Cisplatin mouse
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WebSep 2, 2024 · Animals and Experimental Models. C57BL/6 mice (male, aged 8 weeks) were obtained from the Animal Core Facility of Nanjing Medical University. They were housed individually in cages under hygienic conditions and placed at a constant room temperature (23 ± 1°C) and humidity (30–40%) and maintained in a 12-h light/dark cycle room with …
WebAug 17, 2024 · Cisplatin (cis-Diaminodichloroplatinum, CDDP), one of the most potent chemotherapeutic agents, has been proven effective against various solid tumors, including sarcoma, soft tissue cancer, bone cancer, muscle cancer, and vascular cancer. WebCisplatin (NSC 119875, Cisplatinum, cis-diamminedichloroplatinum II, CDDP, cis DDP, DDP) is an inorganic platinum complex, which is able to inhibit DNA synthesis by …
WebAims: This study investigated the regulatory effect of Mitofusin2 (Mfn2) on mitochondria-associated endoplasmic reticulum membrane (MAMs) integrity and cellular injury in cisplatin-induced acute kidney injury (CP-AKI). Results: CP- AKI mice exhibited decreased expression of Mfn2, increased expression of phosphorylated adenosine monophosphate … WebDec 24, 2024 · In this approach, cisplatin treatment was started when primary tumors were palpable (200–300 mm 3 ). When primary tumors bearing legs reached 15–17 mm (Day 35), three mice from control and...
WebOct 1, 2024 · Cisplatin is a potent chemotherapeutic used for the treatment of many types of cancer. However, its dose-limiting side effect is nephrotoxicity leading to acute kidney …
WebDec 2, 2024 · In the animal model, C57 mice were given weekly injection of 8 mg/kg cisplatin for 4 wk. This led to a sustained decline of kidney function. These mice showed loss of kidney mass, interstitial fibrosis, continued activation of inflammatory cytokines, and appearance of atubular glomeruli. design fashion toysWebOct 1, 2024 · Developing better mouse models to study cisplatin-induced kidney injury Cisplatin-Induced AKI in the Clinical Setting. Although it is a potent choice for first-line … chuck brannanWebOct 7, 2024 · Abstract 1. Introduction In 2024, 18.1 million new cases and 9.5 million cancer-related deaths were diagnosed worldwide. It is... 2. Cisplatin Mouse Models Cisplatin … chuck brandWebCisplatin-nephropathy model mice exhibited elevated levels of serum IS accompanied by elevated levels of blood urea nitrogen and serum creatinine. Furthermore, intraperitoneal administration of IS in mice promoted tumor growth and metastasis. Finally, we found that the MasR agonist Ang-(1-7) suppressed the IS-mediated effects on cell ... chuck brand builders charlotte miWebstudies in mice and rats, cisplatin acted as a tumor initiator follow-ing transplacental exposure via a single intraperitoneal injection late in gestation. In mice, transplacental … design feature of ancient rome furnitureWebMar 16, 2024 · Cisplatin is an alkylating-like platinum-based chemotherapeutic drug commonly used in paediatric oncology [ 5 ]. The understanding of how exposure to cisplatin affects the future fertility of pre-pubertal boys predominantly comes from retrospective follow-up studies [ 6 ]. design featuring two squatting cherubs imagesWebCisplatin can cause fetal harm when administered to a pregnant woman. Cisplatin is mutagenic in bacteria and produces chromosome aberrations in animal cells in tissue culture. In mice cisplatin is teratogenic and embryotoxic. If this drug is used during pregnancy or if the patient becomes design fee for theme park