WebCpG oligodeoxyribonucleotide (CpG-ODN) 7909 sensitized H460R cells when combined with irradiation treatment. The clonogenic capacity was significantly decreased, and the values of D0 and Dq were lower than those of irradiation alone group. The sensitive enhancement ratio (SER) of D0 was 1.224. WebCPG 7909, an immunostimulatory TLR9 agonist oligodeoxynucleotide, as adjuvant to …
Correlation between anthrax lethal toxin neutralizing antibody
WebJan 31, 2024 · Unmethylated cytosine-phosphorothioate-guanine (CpG)-containing oligodeoxynucleotides (ODNs) are synthetic DNA sequences that mimic bacterial DNA, and are known to serve as ligands for Toll‑like receptor 9 (TLR9). The interaction between a CpG ODNs with TLR9 activates the complex downstream cascade that contributes to … WebObjective: To investigate the impact of checkpoint kinase 2 (CHK2)-small interfering RNA … ghl sports
CpG-ODN—Safety Considerations SpringerLink
WebJan 15, 2005 · We conducted a phase 1 study evaluating 4 dose levels of a CpG-ODN (1018 ISS) with rituximab in 20 patients with relapsed non-Hodgkin lymphoma (NHL). Patients received CpG once a week for 4 weeks beginning after the second of 4 rituximab infusions. Adverse events were minimal. ... (CpG 7909; Coley Pharmaceutical Group, Wellesley, … WebCpG ODN could prevent death of challenged animals and to evaluate the effect of the CpG ODN administration schedule on survival, female BALB/c mice (10 per group) were injected i.p. with 100 g (5 mg/kg) of CPG 7909 48 h before challenge, the day of challenge, or 24 h after aerosol challenge (2 LD 50) with B. mallei. We found that CPG 7909 ... WebWe undertook a phase I trial of CPG 7909 (also known as PF-3512676) in patients with previously treated lymphoma with the primary objective of evaluating safety across a range of doses, and secondary objectives of evaluating immunomodulatory effects … ghltp24abk