WebInhibition of CRM1-mediated nuclear export by Leptomycin B resulted in nuclear accumulation of COMMD1. In addition, low oxygen concentrations induced the active export of COMMD1 from the nucleus in a CRM1-dependent manner. Disruption of the NESs in COMMD1 increased the repression of COMMD1 in transcriptional activity of NF-kappa B … WebThe forkhead box transcription factor FOXM1 is considered to be a promising target for cancer therapy. However, the significance of FOXM1 in tumors harboring mutation in …

Prognostic impact and targeting of CRM1 in acute myeloid leuk…

WebCRM1 and Ran-GDP then diffuse back to the nucleus where GEFs exchange GDP to GTP . Because nuclear localization of proteins such as transcription factors is key to their function, and an adequate localization of signaling proteins close to their downstream targets can be imperative for many signal transduction pathways, unbalanced ... WebSep 23, 2007 · To test this, we co-transfected GFP–Crm1 with Flag–WT p53 or Flag–p53EDE/A into p53 −/− MEFs. Similar levels of GFP–Crm1 and Flag–p53 were … nucor hertford address

Nuclear exclusion of p53 in a subset of tumors requires MDM2 …

WebCRM1 inhibition rescued p53-dependent nuclear functions and sensitized NBAT1-depleted cells to genotoxic drugs. Combined inhibition of CRM1 and MDM2 was even more … WebCRM1, p53, and topo IIα protein expression and intracellular localization As shown by immunofluorescence microscopy, baseline CRM1 (green) nuclear localization and overall expression were high in untreated human MM cells and human MM cells treated with the inactive SINE trans-isomer KPT185T (Fig. 2 A, first column). WebMay 16, 2013 · High CRM1 expression was associated with short survival of patients and remained an adverse prognostic factor in multivariate analysis. CRM1 inhibitor KPT-185 induced mainly full-length p53 and apoptosis in a p53-dependent manner, whereas inhibition of proliferation was p53 independent. nucor honduras