Iron in the tumor microenvironment
WebDec 10, 2024 · Iron is required for the proliferation of cancer cells, and its depletion suppresses tumor growth. Eribulin mesylate (eribulin), a non-taxane microtubule inhibitor, disrupts the tumor microenvironment via vascular remodeling and obstruction of the epithelial-mesenchymal transition (EMT). Herein, we investigated the effects of the iron … WebDec 27, 2024 · Iron also plays profound roles in modulating tumor microenvironment and metastasis, maintaining genomic stability and controlling epigenetics. in order to meet the high requirement of iron, neoplastic cells have remodeled iron metabolism pathways, including acquisition, storage, and efflux, which makes manipulating iron homeostasis a ...
Iron in the tumor microenvironment
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WebTransferrin (Tf) is an endogenous protein that transports iron into cells through the cell membrane's TfR. ... the induced disassembly of prodrug nanoparticles can “switch on” the fluorescence of DOX in the tumor microenvironment for tumor imaging. These studies have established the viability of remarkable nanoplatforms for effective cancer ... WebFeb 10, 2024 · Figure 2: Overview of the iron-interplay among tumor cells, T cells, and macrophages in the tumor microenvironment. The anti- The anti- in fl ammatory TAMs adopt an iron-donating phenotype.
WebMar 19, 2024 · In this study, we designed and prepared a tumor microenvironment–induced, absorption spectrum red-shifted, iron-copper co-doped polyaniline (PANI) nanoparticle ( Fe-Cu@PANI ). The Cu (II) ion in these nanoparticles underwent a redox reaction with GSH, which was highly abundant in tumor.
WebApr 18, 2013 · This recent evidence for autocrine or paracrine regulation of iron in the tumour microenvironment represents a new paradigm in iron biology. Cancer cells can … WebApr 14, 2024 · The Tumor Microenvironment and Metastasis Section is a translational research program performing bench-to-beside translational projects involving preclinical …
WebFeb 5, 2024 · Malignant tumor is one of the main causes of death in the world. It has become a major disease that seriously endangers human life and health and restricts social and economic development [1, 2].Traditional methods of cancer treatment mainly include surgical resection, radiotherapy, and chemotherapy [3, 4].However, conventional …
WebApr 12, 2024 · Dual drug loaded superparamagnetic iron oxide nanoparticles for targeted cancer therapy. Biomaterials 31(13), 3694–3706 (2010).Crossref, Medline, CAS, ... Cancer Drug Delivery Systems Based on the Tumor Microenvironment. Springer, Tokyo, Japan, 255–267 (2024). ccsmcs细胞WebApr 14, 2024 · Tumor immune microenvironment (TIME), a tumor-derived immune component, is proven to be closely related to the development, metastasis, and recurrence of tumors. Gut microbiota and its fermented-metabolites short-chain fatty acids (SCFAs) play a critical role in maintaining the immune homeostasis of gastrointestinal tumors. … ccs mcfs 3WebIn this work, a nanoplatform (FeCORM NPs) loaded with an iron-carbonyl complex was constructed. By exploiting chemodynamic therapy (CDT) and immunogenic cell death (ICD)-induced immunotherapy (IMT), the nanoparticles exhibited excellent efficacy against lung metastasis of melanoma in vivo. The iron-carbonyl compound of the nanomaterials could … ccs mcsWebJan 1, 2024 · This is important because patients with colorectal cancer often present with iron deficiency. Iron is necessary for appropriate immunological functions; hence, iron deficiency may hinder cancer immunosurveillance and potentially modify the tumor immune microenvironment, both of which may assist cancer development. butcher daw parkWebJan 1, 2024 · Tumor-associated M2-like macrophages contribute to tumor microenvironment remodeling by removing growth barriers such as the extracellular matrix and promoting vascular growth. In addition, tumor-associated M2-like macrophages promote an immunosuppressive tumor microenvironment that protects cancer cells from … ccsmd stroh ranch assocWebNov 26, 2024 · Abstract and Figures Iron metabolism and tumor biology are intimately linked. Iron facilitates the production of oxygen radicals, which may either result in iron-induced cell death,... butcher danvers maWeb15 hours ago · Distribution of countries/ regions and organizations. In the field of “ferroptosis in cancer”, a total of 2467 organizations from 79 different countries published 3302 articles. 2274 ... butcher date