Nrf2 ferroptosis hcc
Web13 apr. 2024 · Ferroptosis is a newly discovered form of programmed cell death that involves the accumulation of iron-dependent lipid peroxides and plays a vital role in the tumorigenesis, development, and drug resistance of various tumors such as hepatocellular carcinoma (HCC). Web19 mei 2024 · Of interest, blocking the Keap1 antagonized Withaferin A-mediated inhibition in EMT and ferroptosis in HCC cells, and ultimately dampened HCC cell invasion, …
Nrf2 ferroptosis hcc
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Web1 feb. 2024 · The results shown in Fig. 6 (C and D) indicated that NRF2 effectively protected ovarian cancer cells from ferroptosis-inducing compounds; thus, the idea of killing … Web16 mei 2016 · In HCC cells with low levels of NRF2 achieved through RNA interference, sorafenib was found to induce ferroptosis with a higher efficacy . These findings suggest that the NRF2 status could be an important determinant of the response of sorafenib, though it is presently partially unclear which target genes could mediate this effect of NRF2.
Web1 aug. 2024 · And indeed, several studies have shown first promising results concerning the induction of ferroptosis in HCC [16, [25], [26], [27]]. ... Activation of the p62-Keap1 … Web24 sep. 2015 · Oxidative stress, including lipid peroxidation, has been a major inducer of NRF2 expression. In order to examine whether the induction of ferroptosis by erastin, …
Web22 mrt. 2024 · It has been demonstrated that the activation of Nrf2 reduces the killing effect of sorafenib on HCC cells by inhibiting ferroptosis (34, 35). The PI3K/Akt pathway is an … WebWhen NRF2 is activated and causes ROS accumulation, the level of S1R is elevated to protect HCC against sorafenib-induced ferroptosis. 73 To clarify the role of NRF2 in …
WebThe accumulated lipid ROS induced ferroptosis in HCC cells. Additionally, activated Nrf2 suppressed ferroptosis induced by lenvatinib (Figure 4). We demonstrated that the …
Web1 aug. 2024 · Inhibition of NRF2 enhances the sensitivity of HCC cells to DSF/Cu-induced ferroptosis. (A, C) Huh7 cells were treated with DSF/Cu (1 μM) alone or in combination … sheridan small engine repairWeb30 okt. 2024 · In our study, IGF2BP3- NRF2 axis is demonstrated to be a key ferroptosis regulating factor in SF-administered HCC cells both in vitro and in vivo. We also found that IGF2BP3 regulates NRF2 mRNA stability by reading its m6A modification. Section snippets Cell culture and reagents sheridan small business bookkeepingWeb22 dec. 2024 · Ferroptosis is an atypical form of regulated cell death, which is different from apoptosis, necrosis, pyroptosis, and autophagy. Ferroptosis is characterized by iron-dependent oxidative destruction of cellular membranes following the … spud shack in deer park txWeb30 okt. 2024 · In addition, NRF2 mRNA was identified as an important target of IGF2BP3 by bioinformatics analysis, RNA binding protein immunoprecipitation (RIP) and RNA … sheridans manchester rotaWeb6 jul. 2024 · Previous studies have reported that ferroptosis plays a vital role in HCC, and some genes, such as CISD1 11 and the polymorphism of the TP53 gene (S47 variant) … sheridans manchesterWeb22 jan. 2016 · NRF2 . NRF2 has an anti-ferroptosis role in HCC cells. 17 p62 interacts with the NRF2-binding site of Kelch-like ECH-associated protein 1 (Keap1) and competitively … spud shed bottle shopWeb22 aug. 2024 · Researchers have found ferroptosis plays a vital part in HCC (Sun et al. 2016a) and some new drugs (Ou et al. 2024) can induce ferroptosis and more … spudshed bentley opening hours